5-Chloro-2-methoxyphenylhydrazine hydrochloride

Base Information

• Chemical Name: 5-Chloro-2-methoxyphenylhydrazine hydrochloride
• CAS No.: 5446-16-2
• Molecular Formula: C7H10Cl2N2O
• Molecular Weight: 209.075
• Hs Code.: 2928000090
• NSC Number: 17183
• DSSTox Substance ID: DTXSID00373988
• Mol file: 5446-16-2.mol

Synonyms:5446-16-2;5-Chloro-2-methoxyphenylhydrazine hydrochloride;(5-chloro-2-methoxyphenyl)hydrazine hydrochloride;(5-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride;(5-chloro-2-methoxyphenyl)hydrazine;hydrochloride;5-Chloro-2-methoxyphenylhydrazine, HCl;5-chloro-2-methoxyphenylhydrazine hcl;1-(5-chloro-2-methoxyphenyl)hydrazine;SCHEMBL966892;DTXSID00373988;GOMLDPWKBMXMEX-UHFFFAOYSA-N;NSC17183;AM9798;MFCD03196500;NSC-17183;AKOS001476456;(5-chloro-2-methoxy-phenyl)-hydrazine;SB76923;AS-46994;CS-0314710;FT-0692694;5-Chloro-2-methoxyphenylhydrazinehydrochloride;A21620;F11157;EN300-6502979;1-(5-Chloro-2-methoxyphenyl)hydrazine hydrochloride;(5-Chloro-2-methoxyphenyl)hydrazine hydrochloride, AldrichCPR

Chemical Property of 5-Chloro-2-methoxyphenylhydrazine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00275mmHg at 25°C
• Melting Point: 195-196 °C (decomp)
• Refractive Index: 1.619
• Boiling Point: 285.7 °C at 760 mmHg
• Flash Point: 126.6 °C
• PSA: 47.28000
• Density: 1.307 g/cm³
• LogP: 3.20950
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 208.0170183
• Heavy Atom Count: 12
• Complexity: 123

Purity/Quality:

97% ^*data from raw suppliers

(5-Chloro-2-methoxyphenyl)hydrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)NN.Cl
• Uses: (5-Chloro-2-methoxyphenyl)hydrazine Hydrochloride is used as a reactant in the preparation of 2-[1-(5-chloro-2-methoxy-phenyl)-5-methyl-1H-pyrazol-4-yl]-5-aryloxadiazoles with antibacterial activity.

Technology Process of 5-Chloro-2-methoxyphenylhydrazine hydrochloride

There total 1 articles about 5-Chloro-2-methoxyphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-chloro-2-methoxyaniline (95-03-4) → (5-chloro-2-methoxyphenyl)hydrazine hydrochloride (5446-16-2)

Guidance literature:

5-chloro-2-methoxyaniline; With hydrogenchloride; sodium nitrite; In water; at -5 - 0 ℃; for 1h;

With hydrogenchloride; tin(ll) chloride; In water; at -5 - 20 ℃; Concentration; Time;

Reference yield: 70.0%

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate (134653-70-6,51145-57-4) + (5-chloro-2-methoxyphenyl)hydrazine hydrochloride (5446-16-2) → ethyl 1-(5-chloro-2-methoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylate (1198352-87-2)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2009.06.020

Reference yield: 41.0%

(1-tert-butoxycarbonylpiperidine-4-)-carbaldehyde (914654-63-0) + (5-chloro-2-methoxyphenyl)hydrazine hydrochloride (5446-16-2) → C18H25ClN2O2

Guidance literature:

(1-tert-butoxycarbonylpiperidine-4-)-carbaldehyde; (5-chloro-2-methoxyphenyl)hydrazine hydrochloride; In methanol; at 20 ℃; for 2.5h; Inert atmosphere;

With sulfuric acid; at 20 - 50 ℃; Concentration; Reagent/catalyst; Solvent; Temperature; Time;

upstream raw materials:

5-chloro-2-methoxyaniline

Downstream raw materials:

4-[2-(5-chloro-2-methoxy-phenyl)-5-methyl-2H-pyrazol-3-yl]-pyridine

4-[1-(5-chloro-2-methoxy-phenyl)-5-methyl-1H-pyrazol-3-yl]-pyridine

ethyl 1-(5-chloro-2-methoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylate

ethyl 4-chloro-7-methoxy-3-methyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole-3-carboxylate

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