3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

Base Information

Chemical Name:3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester
CAS No.:1025817-16-6
Molecular Formula:C₃₃H₅₀N₂O₈S
Molecular Weight:634.835
Hs Code.:

3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

Synonyms:3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

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Chemical Property of 3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

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Technology Process of 3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

There total 13 articles about 3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70120-30-8,74868-25-0,98719-07-4,98719-08-5,98719-11-0,98719-12-1
<4aR-(4aα,5β,8β,8aα)>-octahydro-5,8-epoxy-1H-2-benzopyran-3-ol

: 1025817-16-6
3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) tBuLi / 1.) ether, -78 deg C, 2.) ether, THF, from -78 deg C to 0 deg C

2: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

3: DMAP, pyridine / 25 °C

4: CrO₃, H₂SO₄ / acetone / 0 - 25 °C

5: aq. NaOH / tetrahydrofuran / 25 °C

6: HCl / 0 °C

7: CrO₃, H₂SO₄ / acetone / 25 °C

8: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

9: (iPr)2NEt / CH₂Cl₂ / 0 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; dmap; sodium hydroxide; sulfuric acid; hydrogen; tert.-butyl lithium; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013

Reference yield:

: 133027-56-2
<3-(2-bromophenyl)propoxy>dimethyl(1,1,2-trimethylpropyl)silane

: 1025817-16-6
3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) tBuLi / 1.) ether, -78 deg C, 2.) ether, THF, from -78 deg C to 0 deg C

2: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

3: DMAP, pyridine / 25 °C

4: CrO₃, H₂SO₄ / acetone / 0 - 25 °C

5: aq. NaOH / tetrahydrofuran / 25 °C

6: HCl / 0 °C

7: CrO₃, H₂SO₄ / acetone / 25 °C

8: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

9: (iPr)2NEt / CH₂Cl₂ / 0 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; dmap; sodium hydroxide; sulfuric acid; hydrogen; tert.-butyl lithium; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013

Reference yield:

: 1-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-phenyl)-2-((1S,2R,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethanol

: 1025817-16-6
3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

2: DMAP, pyridine / 25 °C

3: CrO₃, H₂SO₄ / acetone / 0 - 25 °C

4: aq. NaOH / tetrahydrofuran / 25 °C

5: HCl / 0 °C

6: CrO₃, H₂SO₄ / acetone / 25 °C

7: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

8: (iPr)2NEt / CH₂Cl₂ / 0 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; dmap; sodium hydroxide; sulfuric acid; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013