133027-56-2

Basic information

• Product Name: Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)-
• CAS NO: 133027-56-2
• Molecular Formula: C17H29BrOSi
• Molecular Weight: 357.406
• Mol File: 133027-56-2.mol

Chemical Properties

• CAS DataBase Reference: Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)-(133027-56-2)
• EPA Substance Registry System: Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)-(133027-56-2)

Safety Data

• Hazardous Substances Data: 133027-56-2(Hazardous Substances Data)

Usage

Uses

Used in Silicone Production:
Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)is used as a precursor in the production of silicones for its ability to contribute to the formation of siloxane bonds, which are the backbone of silicone polymers. These polymers are valued for their thermal stability, flexibility, and resistance to environmental degradation.
Used as a Coupling Agent in Organic Synthesis:
In the chemical industry, Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)serves as a coupling agent, facilitating the formation of covalent bonds between different molecular entities. Its unique structure allows it to act as a bridge, enhancing the reactivity and selectivity of certain chemical reactions, which is crucial in the synthesis of complex organic compounds.
Used in Coatings and Adhesives Industry:
Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)is used as a component in the development of high-performance coatings and adhesives. Its role in these formulations is to improve adhesion, durability, and resistance to various environmental factors, such as UV radiation and moisture.
Used in Electronic Industry:
In the electronics sector, this silane compound is utilized in the creation of materials with specific electrical and thermal properties. It may be employed in the fabrication of semiconductor devices or as a component in the production of electronic-grade adhesives and encapsulants, which protect sensitive electronic components from environmental factors and mechanical stress.
Used in Pharmaceutical and Biochemical Research:
Silane, [3-(2-bromophenyl)propoxy]dimethyl(1,1,2-trimethylpropyl)may also find application in pharmaceutical and biochemical research, where its unique structure could be leveraged to develop new drug candidates or as a tool in the study of biological systems and interactions. Its potential use in this field could be for targeting specific receptors or as a component of drug delivery systems.

Upstream product

• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 67373-56-2 chlorodimethyl(1,1,2-trimethylpropyl)silane 
• 66191-86-4 3-(2-bromophenyl)propanoic acid,methyl ester 
• 102540-15-8 methyl (2E)-3-(2-bromophenyl)-2-propenoate 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 133027-57-3 [1S-(1α,2α,3α,4α)]-α-[2-[3-[[Dimethyl-(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol 
• 1026467-43-5 3-{2-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-propionic acid 
• 149079-79-8 3-{2-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-propionic acid methyl ester 
• 1025912-18-8 3-{2-[2-((1S,2R,3R,4R)-3-Acetoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-propionic acid 
• 149079-86-7 (1R,2S,3R,4S)-3-{2-[2-(2-Methoxycarbonyl-ethyl)-phenyl]-ethyl}-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid 
• 1026377-25-2 3-[2-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester 
• 1026440-06-1 3-[2-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester 
• 1027928-29-5 3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester 
• 1025817-16-6 3-[2-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-methanesulfonyloxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-propionic acid methyl ester 
• 142758-00-7 3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid 
• 135682-53-0 <1S-1α,2α,3α,4α>-2-<<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzenepropanoic acid, methyl ester 
• 135613-49-9 (1R,2S,3R,4S)-3-[2-(3-formyl-7-oxabicyclo[2.2.1]hept-2-yl-methyl)phenyl]propionic acid methyl ester 
• 142757-90-2 [1S-(1α,2α,3α,4α)]-2-[[3-[(Acetyloxy)methyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]benzenepropanoic acid 
• 135613-44-4 <1S-1α,2α,3α,4α>-2-<<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzenebutanoic acid, methyl ester 

Relevant articles and documents

Prostaglandin analogs

Thromboxane receptor antagonist activity is exhibited by compounds of the formula STR1 wherein: V is --(CH 2) m --, --O--, or STR2 but if V is --O--or STR3 R 3 and R 4 must complete an aromatic ring; W is --(CH 2) 2 --, --CH CH-- or phenylene;X is a single bond, --CH CH--, --(CH 2) n --, or --O--(CH 2) n --; or X is branched alkylene or --O--branched alkylene wherein W is linked to Y through a chain n carbon atoms long;Y is --CO 2 H, --CO 2 alkyl, --CO 2 alkali metal, --CH 2 OH, --CONHSO 2 R 5, --CONHR 6, or --CH 2 -5-tetrazolyl;Z is O or NH;R 3 and R 4 are each independently hydrogen or alkyl or R 3 and R 4 together complete a ring optionally substituted through a ring carbon with a halo, lower alkyl, phenyl, halo (lower alkyl), halophenyl, oxo or hydroxyl group; and the remaining symbols are as defined in the specification.

Substituted styryl heterocyclic amido prostaglandin analogs.

Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula STR1 wherein: Cm Hp is an alkylene chain wherein m is 0, 1, 2, or 3 and p=(2×m)-1, except that when m is 0, p is also 0; n is 0

7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease

7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula STR1 wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH2)2 --, --CH=CH-- or STR2 wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is STR3 then Y cannot be O, and when Z is --CH=CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO2 H, CO2 lower alkyl, CH2 OH, CO2 alkali metal, CONHSOR3, CONHR3a or --CH2 -5-tetrazolyl, X is O, S or NH; and where R1, R2, R3 and R3a are as defined herein.

Heterocyclic amido prostaglandin analogs

Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula STR1 wherein: m is 1, 2, or 3; n is 0, 1, 2 or 3; R is CO2 R', CH2 OH, CONHSO2 Rhu 3, CONHR4,

7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease

7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasopastic disease have the structural formula STR1 wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH2)2 --, --CH=CH-- or STR2 wherein Y is O, a single bond or vinyl, with the proviso that when n is 0, if Z is STR3 then Y cannot be O, and Z is --CH=CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO2 H, CO2 lower alkyl, CH2 OH, CO2 alkali metal, CONHSOR3, CONHR3a or --CH2 --5-tetrazolyl, X is O, S or NH; and where R1, R2, R3 and R3a are as defined herein.

Anti-thrombotic heterocyclic amido prostaglandin analogs

Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula STR1 wherein: m is 1, 2 or 3: n is 1, 2 or 3, except that n is O when Y is vinylene; p is 1, 2 or 3; R is CO2 R', CH2 OH, CONHS

Heterocyclic ketone prostaglandin analogs

Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula STR1 wherein: m is 1, 2, or 3; n is 0, 1, 2 or 3; R1 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl cycloalkyl, cycloalkylalkyl, cycl

Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone ω-chains

A series of chiral interphenylene 7-oxabicyclo[2.2.1]heptane semicarbazones 19-26 were prepared and evaluated for their in vitro thromboxane (TxA2) antagonistic activity and in vivo duration of action. The potency of 19-26 was found to be highly dependent on the substitution pattern of the interphenylene ring and decreased in the order ortho > meta >> para. SQ 35,091 (25), [1S-(1α,2α,3α,4α)]-2-[[3-[[[(phenylamino)carbonyl]hydrazono] methyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]benzenepropanoic acid, was identified as a potent and long-acting TxA2 antagonist. In human platelet rich plasma SQ 35,091 inhibited arachidonic acid (800 μM) and U-46,619 (10 μM) induced aggregation with I50 values of 3 and 12 nM, respectively. In contrast, no inhibition of ADP (20 μM) induced aggregation was observed at >1000 μM. Receptor binding studies with [3H]-SQ 29,548 showed SQ 35,091 was a competitive antagonist with a K(d) value of 1.0 ± 0.1 nM in human platelet membranes. In vivo SQ 35,091 (0.2 mg/kg po) showed extended protection (T50 = 16 h) from U-46,619 (2 mg/kg iv) induced death in mice. These compounds have for the first time demonstrated that a metabolically stable interphenylene α-sidechain can be introduced into a prostanoid-like series of TxA2 antagonists with the maintenance of potent antagonistic activity.

7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease

7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula STR1 wherein m is 0, 1, 2, 3 or 4; n is 1, 2 or 3; and p is 1, 2 or 3; Z is --CH=CH--, --CH2 CH2 -- or STR2 wherein Y is 1 or a single bond; R is CO2 H, CO2 lower alkyl, CO2 alkali metal, CONHSO2 R2 (wherein R2 is lower alkyl or aryl) or --CH2 -5-tetrazolyl; A is CHOH, C=O, STR3 (wherein R3 is H or lower alkyl), or a single bond; R1 is lower alkyl, aryl, cycloalkyl or H, R1 can be H only when A is a single bond.