1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

Base Information

Chemical Name:1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide
CAS No.:130235-44-8
Molecular Formula:C₁₄H₁₃Cl₂N₃O₃S
Molecular Weight:374.248
Hs Code.:

Synonyms:1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

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Chemical Property of 1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

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Technology Process of 1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

There total 9 articles about 1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 130235-43-7,130236-23-6
1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S-oxide

: 130235-44-8
1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1248/cpb.38.1258

Reference yield:

: 130235-08-4
2-(3-hydroxypropylthio)-2',4'-dichloroacetophenone

: 130235-44-8
1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

Guidance literature:: Multi-step reaction with 8 steps

1: 71 percent / Et₃N / CH₂Cl₂ / 0.08 h / -15 °C

2: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / 50 - 55 °C

3: 71 percent / MCPBA / CH₂Cl₂ / 0.17 h / 0 °C

4: 100 percent / trifluoroacetic anhydride, 2,6-lutidine / acetonitrile / 0.08 h / 0 °C

5: 53 percent / n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

6: 60 percent / dimethylformamide / 2 h / 95 °C

7: 69 percent / MCPBA / CH₂Cl₂ / 0 °C

8: 84 percent / MCPBA / CH₂Cl₂

With 2,6-dimethylpyridine; n-butyllithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.38.1258

Reference yield:

: 130235-40-4
2,4-dichlorophenyl 2-thiolen-2-yl ketone

: 130235-44-8
1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol S,S-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

2: 60 percent / dimethylformamide / 2 h / 95 °C

3: 69 percent / MCPBA / CH₂Cl₂ / 0 °C

4: 84 percent / MCPBA / CH₂Cl₂

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.1258