6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Base Information

Chemical Name:6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester
CAS No.:623143-86-2
Molecular Formula:C₂₀H₂₇NO₆
Molecular Weight:377.437
Hs Code.:

Synonyms:6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Suppliers and Price of 6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

There total 6 articles about 6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77119-85-8
N-(tert-butoxycarbonyl)-D-phenylalaninal

: 623143-86-2
6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: LiClO₄ / diethyl ether / 20 °C

2: 79 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / 0 °C

3: p-TsOH / 12 h / 80 °C

4: aq. KOH / ethanol / 1 h / Heating

5: aq. AcOH / tetrahydrofuran / 12 h / 60 °C

6: methanol / 20 °C

With potassium hydroxide; boron trifluoride diethyl etherate; lithium perchlorate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 1: hetero Diels-Alder cyclization;
DOI:10.1016/S0968-0896(03)00274-8

Reference yield:

: 524018-08-4
[1-(4-oxo-3,4-dihydro-2H-pyran-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 623143-86-2
6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / 0 °C

2: p-TsOH / 12 h / 80 °C

3: aq. KOH / ethanol / 1 h / Heating

4: aq. AcOH / tetrahydrofuran / 12 h / 60 °C

5: methanol / 20 °C

With potassium hydroxide; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0968-0896(03)00274-8

Reference yield:

: 623143-65-7
[1-(6R-cyano-4-oxo-tetrahydro-pyran-2R-yl)-2R-phenylethyl]carbamic acid tert-butyl ester

: 623143-86-2
6R-(1R-tert-butoxycarbonylamino-2-phenyl-ethyl)-4-oxo-tetrahydro-pyran-2S-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / 12 h / 80 °C

2: aq. KOH / ethanol / 1 h / Heating

3: aq. AcOH / tetrahydrofuran / 12 h / 60 °C

4: methanol / 20 °C

With potassium hydroxide; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0968-0896(03)00274-8