2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine

Base Information

• Chemical Name: 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine
• CAS No.: 1275593-61-7
• Molecular Formula: C₆₄H₇₇N₁₃Si
• Molecular Weight: 1056.49
• Mol file: 1275593-61-7.mol

Synonyms:2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine

Chemical Property of 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine

There total 14 articles about 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-(1-(4-azidophenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine (1275593-66-2) + 4,4'-(5-ethynyl-1,3-phenylene)bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazole) (1275593-68-4) → 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine (1275593-61-7)

Guidance literature:

With copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine; In tetrahydrofuran; at 40 ℃; for 17h; Inert atmosphere;

DOI:10.1039/c0jm03117h

Reference yield:

2,5-dibromopyridine (624-28-2) → 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine (1275593-61-7)

Guidance literature:

Multi-step reaction with 5 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 22 h / 60 °C / Inert atmosphere

3: potassium carbonate / tetrahydrofuran; methanol / 16 h / 20 °C

4: copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 15 h / Inert atmosphere

5: copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 17 h / 40 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N,N',N'',N'''-pentamethyldiethylenetriamine; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling / 2: Sonogashira coupling;

DOI:10.1039/c0jm03117h

Reference yield:

C27H38O2Si (1275593-71-9) → 2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-((triisopropylsilyl)ethynyl)pyridine (1275593-61-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / toluene / Reflux

2: copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 18 h / 40 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 2.5 h / 20 °C

4: copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 17 h / 40 °C / Inert atmosphere

With copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine; tetrabutyl ammonium fluoride; water; sodium hydroxide; In tetrahydrofuran; toluene;

DOI:10.1039/c0jm03117h

upstream raw materials:

2,5-dibromopyridine

1-bromo-3,5-bis(3'-hydroxy-3'-methylbut-1'-ynyl)benzene

1-azido-3,5-di-tert-butylbenzene

5-((triisopropylsilyl)ethynyl)-2-((trimethylsilyl)ethynyl)pyridine

Downstream raw materials:

2-(1-(4-(4-(3,5-bis(1-(3,5-di-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)-5-ethynylpyridine

Refernces