Technology Process of methyl 4-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzoate 2,2,2-trifluoroacetate
There total 8 articles about methyl 4-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzoate 2,2,2-trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-(2-methylpyrrolidin-1-yl)pyridin-2-amine; Methyl 4-(8-bromo-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzoate;
With
caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
1,4-dioxane;
at 20 ℃;
for 16.16h;
Inert atmosphere;
Reflux;
trifluoroacetic acid;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile / 72 h / 20 °C
2.1: isopropyl alcohol / Inert atmosphere; Reflux
2.2: 50 °C
3.1: trifluoroacetic anhydride / tetrahydrofuran / 0 - 20 °C
3.2: pH 8
4.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 20 - 96 °C / Inert atmosphere
5.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)} / 1,4-dioxane / 16.16 h / 20 °C / Inert atmosphere; Reflux
With
N-Bromosuccinimide; sodium carbonate; caesium carbonate; trifluoroacetic anhydride;
tris-(dibenzylideneacetone)dipalladium(0); Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropyl alcohol / Inert atmosphere; Reflux
1.2: 50 °C
2.1: trifluoroacetic anhydride / tetrahydrofuran / 0 - 20 °C
2.2: pH 8
3.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 20 - 96 °C / Inert atmosphere
4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)} / 1,4-dioxane / 16.16 h / 20 °C / Inert atmosphere; Reflux
With
sodium carbonate; caesium carbonate; trifluoroacetic anhydride;
tris-(dibenzylideneacetone)dipalladium(0); Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)};
In
tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol;
