4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

Base Information

Chemical Name:4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione
CAS No.:252561-74-3
Molecular Formula:C₁₄H₁₀F₃NO₂S
Molecular Weight:313.3
Hs Code.:

Synonyms:4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

Chemical Property:

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Technology Process of 4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

There total 3 articles about 4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 252561-73-2
1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1-ethanone

: 383-63-1
ethyl trifluoroacetate,

: 252561-74-3
4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

Guidance literature:: With hydrogenchloride; sodium methylate; In methanol; tert-butyl methyl ether;

Reference yield:

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

: 252561-74-3
4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / 0.25 h / -40 °C

2: Pd(PPh₃)4; LiCl / dioxane / 110 °C

3: NaOMe / 1,2-dimethoxy-ethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; triethylamine; lithium chloride; In 1,4-dioxane; 1,2-dimethoxyethane; 3: Claisen condensation;
DOI:10.1016/j.bmcl.2006.01.059

Reference yield:

: 252561-07-2
4-acetyl-2-methylphenyl trifluoromethanesulfonate

: 252561-74-3
4,4,4-Trifluoro-1-[3-methyl-4-(1,3-thiazol-4-yl)phenyl]-1,3-butanedione

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)4; LiCl / dioxane / 110 °C

2: NaOMe / 1,2-dimethoxy-ethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; lithium chloride; In 1,4-dioxane; 1,2-dimethoxyethane; 2: Claisen condensation;
DOI:10.1016/j.bmcl.2006.01.059