2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid
CAS No.:1358916-57-0
Molecular Formula:C₂₃H₂₁NO₅
Molecular Weight:391.423
Hs Code.:

Synonyms:2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

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Chemical Property of 2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

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Technology Process of 2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

There total 6 articles about 2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1358916-54-7
diethyl 2-(8-(benzyloxy)quinoline-2-yl)cyclopropane-1,1-dicarboxylate

: 1358916-57-0
2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

Guidance literature:: diethyl 2-(8-(benzyloxy)quinoline-2-yl)cyclopropane-1,1-dicarboxylate; With sodium hydroxide; In ethanol; at 20 ℃; for 12h;

With potassium hydrogensulfate; In ethanol;
DOI:10.1016/j.ejmech.2011.12.037

Reference yield:

: 1358916-49-0
diethyl 2-((8-(benzyloxy)quinoline-2-yl)methylene)malonate

: 1358916-57-0
2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere

1.2: 15 - 60 °C

2.1: sodium hydroxide / ethanol / 12 h / 20 °C

With sodium hydride; sodium hydroxide; In ethanol; dimethyl sulfoxide; mineral oil;
DOI:10.1016/j.ejmech.2011.12.037

Reference yield:

: 93315-49-2
2-methyl-8-(benzyloxy)quinoline

: 1358916-57-0
2-(8-(benzyloxy)quinolin-2-yl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: selenium(IV) oxide / 1,4-dioxane / 12 h / 95 °C / Inert atmosphere; Molecular sieve

2.1: piperidine; acetic acid / toluene / 20 h / Reflux

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere

3.2: 15 - 60 °C

4.1: sodium hydroxide / ethanol / 12 h / 20 °C

With piperidine; selenium(IV) oxide; sodium hydride; acetic acid; sodium hydroxide; In 1,4-dioxane; ethanol; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1016/j.ejmech.2011.12.037