93315-49-2Relevant articles and documents
A novel quinoline derivative containing a phenanthroimidazole moiety: Synthesis, physical properties and light-emitting diodes application
Shao, Xiaona,Liu, Wenzhu,Guo, Ruike,Chen, Junfeng,Zhou, Nonglin
, (2021/02/09)
The deep-blue emitting material 2-(8-(benzyloxy)quinolin-2-yl)-1-phenyl-1H-phenanthro[9,10-d]imidazole (QL-PPI) which contains 8-(Benzyloxy)quinoline core and phenanthroimidazole moiety, has been designed and synthesized. The non-doped OLED using QL-PPI a
2-carboxyl piperazine linked tacrine-8-amino(hydroxyl) quinoline derivative as well as preparation and application
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Paragraph 0077-0080, (2019/08/06)
The invention relates to the technical field of chemical synthesis, and specifically relates to a 2-carboxyl piperazine linked tacrine-8-amino(hydroxyl) quinoline derivative as well as preparation andapplication. The 2-carboxyl piperazine linked tacrine-8-amino(hydroxyl) quinoline derivative is a chemical compound shown in a formula I (the formula I is shown in the description) or a pharmaceutically acceptable salt thereof, and a solvent chemical compound, an enantiomer, a diastereoisomer, a tautomer or a mixture in any proportion of the chemical compound shown in the formula I or the pharmaceutically acceptable salt thereof, and includes a racemic mixture. Confirmed by a pharmacological test, the kind of chemical compound has an inhibiting effect on the activity of acetylcholinesterase(AChE) and butyrylcholinesterase(BuChE), and belongs to a cholinesterase inhibitor; the chemical compound also has an inhibiting effect on self-aggregation of beta-amyloid protein, and has delayed action on hydrolysis of acetylcholine and self-aggregation of the beta-amyloid protein, thereby improving the effect of the acetylcholine on a synapse, and finally realizing the purpose of effectively treating alzheimer's disease (AD).
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease
Hu, Jinhui,Pan, Tingting,An, Baijiao,Li, Zhengcunxiao,Li, Xingshu,Huang, Ling
, p. 512 - 526 (2019/01/03)
Considering the importance of PDE4D inhibition and the modulation of biometals in Alzheimer's disease (AD) therapeutics, we have designed, synthesized and evaluated a series of new clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands fo
MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS
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Page/Page column 27; 28, (2017/02/28)
Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases.
MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS
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Paragraph 0136 - 0138, (2014/10/16)
Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases.
MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS
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Page/Page column 18, (2014/10/18)
Novel quinolone derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases. In an aspect, the invention relates to a composition comprising a therapeutically effective amount of the compound as aforemen
Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation
Oliveri, Valentina,Attanasio, Francesco,Puglisi, Antonino,Spencer, John,Sgarlata, Carmelo,Vecchio, Graziella
supporting information, p. 8954 - 8964 (2014/07/22)
Mounting evidence suggests a pivotal role of metal imbalances in protein misfolding and amyloid diseases. As such, metal ions represent a promising therapeutic target. In this context, the synthesis of chelators that also contain complementary functionali
Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
Lam, Kim-Hung,Gambari, Roberto,Lee, Kenneth Ka-Ho,Chen, Yi-Xin,Kok, Stanton Hon-Lung,Wong, Raymond Siu-Ming,Lau, Fung-Yi,Cheng, Chor-Hing,Wong, Wai-Yeung,Bian, Zhao-Xiang,Chan, Albert Sun-Chi,Tang, Johnny Cheuk-On,Chui, Chung-Hin
, p. 367 - 370 (2015/02/19)
This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.
Synthesis, characterization and luminescence of gold complexes bearing an NHC ligand based on the imidazo[1,5-a]quinolinol scaffold
Kriechbaum, Margit,Winterleitner, Gerda,Gerisch, Alexander,List, Manuela,Monkowius, Uwe
, p. 5567 - 5575 (2013/11/19)
We report on the synthesis and characterization of an NHC ligand based on the imidazo[1,5-a]quinolinol scaffold. The benzyl-protected NHC precursor was used for the preparation of the corresponding AgI, AuI and AuIII compl
Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6- substituted-4,6-diazaspiro[2,4]heptane-5,7-diones
He, Xianran,Zhong, Min,Zhang, Tao,Yang, Jin,Wu, Zhongyuan,Xiao, Yuling,Guo, Hao,Qiu, Guofu,Hu, Xianming
experimental part, p. 338 - 346 (2012/03/22)
In the present study on the development of new anticonvulsants, 16 new1-(8-(benzyloxy)quinolin-2-yl-6-substituted-4,6-diazaspiro[2,4]heptane-5, 7-diones were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES), subcutan
