(2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate

Base Information

• Chemical Name: (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate
• CAS No.: 145746-12-9
• Molecular Formula: C₃₂H₅₂O₆S₂Si₂
• Molecular Weight: 653.064

Synonyms:(2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate

Chemical Property of (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate

There total 2 articles about (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

t-butyldimethylsiyl triflate (69739-34-0) + (2E)-Methyl 2-<(E)-1'-<2-(2''',2'''-Dimethoxyethyl)-1,3-dithian-2-yl>-4'-oxopent-2-enyloxymethyl>-3-propenoate (145746-20-9) → (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate (145746-12-9)

Guidance literature:

With triethylamine; In dichloromethane; at -20 ℃; for 0.5h;

DOI:10.1039/P19920002763

Reference yield:

(E)-methyl 2-<<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>(formyl)ethoxymethyl>-3-dimethyl(phenyl)silylprop-2-enoate (145745-81-9) → (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate (145746-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / LiCl, iPr₂EtN / dimethylformamide

2: 86 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/P19920002763

Reference yield: 32.0%

(2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate (145746-12-9) → (1R*,3aS*,4S*,7aR*)-Methyl 6-(tert-Butyldimethylsiloxy)-1-<2'-(2'',2''-dimethoxyethyl)-1',3'-dithian-2'-yl>-4--1,4,5,7a-tetrahydro-3H-isobenzofuran-3a-carboxylate (145746-30-1,145746-31-2) + (1R*,3aR*,4R*,7aR*)-Methyl 6-(tert-Butyldimethylsiloxy)-1-<2'-(2'',2''-dimethoxyethyl)-1',3'-dithian-2'-yl>-4--1,4,5,7a-tetrahydro-3H-isobenzofuran-3a-carboxylate (145746-30-1,145746-31-2)

Guidance literature:

In toluene; for 14h; Yields of byproduct given; Heating;

DOI:10.1039/P19920002763

upstream raw materials:

t-butyldimethylsiyl triflate

(2E)-Methyl 2-<(E)-1'-<2-(2''',2'''-Dimethoxyethyl)-1,3-dithian-2-yl>-4'-oxopent-2-enyloxymethyl>-3-propenoate

(E)-methyl 2-<<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>(formyl)ethoxymethyl>-3-dimethyl(phenyl)silylprop-2-enoate

Downstream raw materials:

(1R^*,3aS^*,4S^*,7a^R*)-Methyl 6-(tert-Butyldimethylsiloxy)-1-<2'-(2'',2''-dimethoxyethyl)-1',3'-dithian-2'-yl>-4--1,4,5,7a-tetrahydro-3H-isobenzofuran-3a-carboxylate

(1R^*,3aR^*,4R^*,7a^R*)-Methyl 6-(tert-Butyldimethylsiloxy)-1-<2'-(2'',2''-dimethoxyethyl)-1',3'-dithian-2'-yl>-4--1,4,5,7a-tetrahydro-3H-isobenzofuran-3a-carboxylate

(1R^*,3aS^*,4S^*,7a^R*)-Methyl 4-Dimethyl(phenyl)silyl-1-<2'-(formylmethyl)-1',3'-dithian-2'-yl>-6-oxoperhydroisobenzofuran-3a-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 145746-12-9 (2E)-Methyl 2-<(E)-4'-tert-Butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>penta-2',4'-dienyloxymethyl>-3-propenoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send