6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

Base Information

Chemical Name:6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione
CAS No.:135714-96-4
Molecular Formula:C₂₀H₁₈O₄
Molecular Weight:322.361
Hs Code.:

Synonyms:6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

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Chemical Property of 6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

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Technology Process of 6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

There total 5 articles about 6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6,7,8,9-tetrahydro-2,3-dimethoxy-9-oxo-5-phenyl-5H-benzocycloheptene-5-carboxylic acid

: 135714-96-4
6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

Guidance literature:: With sulfuric acid; In ethanol; for 1h; Heating;

Reference yield: 67.0%

: 633301-45-8
diethyl 2-(3,4-dimethoxyphenyl)-2-phenylhexanedioate

: 135714-96-4
6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

Guidance literature:: With trifluoroacetic acid; trifluoroacetic anhydride; at 70 ℃; for 20h;

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 135714-96-4
6,7,8,9-tetrahydro-2,3-dimethoxy-9-phenyl-6,9-methano-5H-benzocycloheptene-5,10-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 98percent H₂SO₄, gl. acetic acid / 1) 70 deg C, 1.5 h, 2) reflux, overnight

2: 1) LDA, 2) HMPA / 1) THF, -72 deg C, 0.5 h, 2a) THF, 1 h, -72 deg C, b) -72 deg C to rt, overnight

3: 67 percent / trifluoroacetic anhydride, trifluoroacetic acid / 20 h / 70 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; acetic acid; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide;