[(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:168773-37-3
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:[(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

Suppliers and Price of [(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

There total 8 articles about [(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 667870-36-2
(S)-5-((R)-1-Azido-2-benzyloxy-ethyl)-dihydro-furan-2-one

: 168773-37-3
[(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2004.11.101

Reference yield: 65.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 168773-26-0
(5S)-5-<(1R)-1-<(9-Phenyl-9-fluorenyl)amino>-2-(benzyloxy)ethyl>dihydrofuran-2(3H)-one

: 168773-37-3
[(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; 10% palladium on active carbon; In methanol;
DOI:10.1021/jo00119a044

Reference yield:

: 100-39-0
benzyl bromide

: 168773-37-3
[(R)-2-Benzyloxy-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaH, TBAI / tetrahydrofuran / 1.) r.t., 5 min, 2.) 24 h

2: 99 percent / LiAlH₄ / tetrahydrofuran / 0.67 h

4: 65 percent / H₂ / 10percentPd/C / methanol

With lithium aluminium tetrahydride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; 10% palladium on active carbon; In tetrahydrofuran; methanol;
DOI:10.1021/jo00119a044