Technology Process of (rac)-(E)-4-(4-hydroxy-2,6,6-trimethyl-2-cyclohexen-1-yl)-2,2-ethylenedioxy-3-butene
There total 3 articles about (rac)-(E)-4-(4-hydroxy-2,6,6-trimethyl-2-cyclohexen-1-yl)-2,2-ethylenedioxy-3-butene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
at 10 - 20 ℃;
for 4h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid; trimethyl orthoformate / hexane / 20 °C / Inert atmosphere
2: potassium carbonate; tert.-butylhydroperoxide; sodium hypochlorite / acetonitrile; water / 9.5 h / -5 - 0 °C / Inert atmosphere; Cooling with ice-salt
3: sodium tetrahydroborate / ethanol / 4 h / 10 - 20 °C
With
tert.-butylhydroperoxide; sodium hypochlorite; sodium tetrahydroborate; potassium carbonate; toluene-4-sulfonic acid; trimethyl orthoformate;
In
ethanol; hexane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; tert.-butylhydroperoxide; sodium hypochlorite / acetonitrile; water / 9.5 h / -5 - 0 °C / Inert atmosphere; Cooling with ice-salt
2: sodium tetrahydroborate / ethanol / 4 h / 10 - 20 °C
With
tert.-butylhydroperoxide; sodium hypochlorite; sodium tetrahydroborate; potassium carbonate;
In
ethanol; water; acetonitrile;
