10.1007/s13738-019-01784-2
The research details the development of a novel and practical route for the total synthesis of canthaxanthin, a commercially significant carotenoid with applications in poultry feed and potential health benefits. The synthesis process begins with the epoxidation of α-ionone using metachloroperbenzoic acid, followed by a series of reactions including isomerization, Darzens condensation, Wittig–Horner condensation, and oxidation, ultimately yielding canthaxanthin with an overall yield of 37% from α-ionone. Key chemicals used throughout the process include α-ionone, metachloroperbenzoic acid, sodium methoxide, methyl chloroacetate, tetraethyl methylenebisphosphonate, potassium tert-butoxide, and aluminum isopropoxide. The study concludes that the developed route is practical for large-scale production due to its simplicity and the ease with which key building blocks can be prepared.
10.1016/j.bmcl.2012.10.110
The research aimed to synthesize and evaluate novel terpenyl heterocycles based on chalcones and their dihydropyrazolidines/pyrazolidines for their potential as antileishmanial agents against Leishmania donovani, a parasite causing leishmaniasis. The study identified compound 4d as a promising candidate with significant in vitro activity against intracellular amastigotes of L. donovani, exhibiting an IC50 value of 7.49 μM and a selectivity index (S.I.) of 29.46, which was more active than the reference drug miltefosine. Compound 4d also showed a significant in vivo response in a hamster model with 81% inhibition of parasite multiplication. The chemicals used in the synthesis process included substituted aromatic aldehydes, b-ionone, and a-ionone for the chalcones, phenyl hydrazine for the formation of dihydropyrazolidine derivatives, and Ag2O for the aromatization of certain compounds. The study concluded that these terpenyl heterocycles could serve as prototypes for the development of more efficacious antileishmanial agents.
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