1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea

Base Information

• Chemical Name: 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea
• CAS No.: 1422728-82-2
• Molecular Formula: C₃₅H₅₆N₄O₂
• Molecular Weight: 564.855
• Mol file: 1422728-82-2.mol

Synonyms:1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea

Chemical Property of 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea

There total 4 articles about 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-amino-6-(dec-9-enyl)-5-(2-ethylhexyl)pyrimidin-4(1H)-one (1422728-81-1) + 2,6-diisopropylphenyl isocyanate (28178-42-9) → 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea (1422728-82-2)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1002/anie.201204840

Reference yield:

C23H42O3 (1443253-63-1) → 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea (1422728-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Reflux

2: pyridine / 20 °C

With pyridine; In ethanol;

DOI:10.1002/anie.201204840

Reference yield:

9-bromo-1-nonene (89359-54-6) → 1-(6-(dec-9-enyl)-5-(2-ethylhexyl)-4-oxo-1,4-dihydropyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea (1422728-82-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 0.5 h / -78 °C

1.3: -78 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C

3.1: ethanol / 24 h / Reflux

4.1: pyridine / 20 °C

With pyridine; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/anie.201204840

upstream raw materials:

2-amino-6-(dec-9-enyl)-5-(2-ethylhexyl)pyrimidin-4(1H)-one

2,6-diisopropylphenyl isocyanate

9-bromo-1-nonene

ethyl 3-oxotridec-12-enoate

Downstream raw materials:

1-(2,6-diisopropylphenyl)-3-(5-(2-ethylhexyl)-4-(10-hydroxydecyl)-6-(4-methoxybenzyloxy)pyrimidin-2-yl)urea

C₅₀H₇₆N₄O₅S₃

1-(4-(dec-9-enyl)-5-(2-ethylhexyl)-6-(4-methoxybenzyloxy)pyrimidin-2-yl)-3-(2,6-diisopropylphenyl)urea