(2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

Base Information

Chemical Name:(2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en
CAS No.:1358918-35-0
Molecular Formula:C₃₇H₅₄O₃Si₂
Molecular Weight:603.005
Hs Code.:

Synonyms:(2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

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Chemical Property of (2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

Chemical Property:

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Technology Process of (2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

There total 9 articles about (2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1358918-41-8
(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

: 1358918-35-0
(2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

Guidance literature:: With pyridine; hydrogen; In methanol; for 1h;
DOI:10.1021/ol203088g

Reference yield:

: C₁₂H₁₆O₄S

: 1358918-35-0
(2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile / 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4.1: pyridine; hydrogen / methanol / 1 h

With pyridine; 1H-imidazole; sodium periodate; n-butyllithium; ruthenium(III) chloride trihydrate; hydrogen; In tetrahydrofuran; methanol; hexanes; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol203088g

Reference yield:

: 1358918-34-9
(5S)-8-benzyloxy-1-(tert-butyldiphenylsilyloxy)oct-2-yn-5-ol

: 1358918-35-0
(2Z,5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-en

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: pyridine; hydrogen / methanol / 1 h

With pyridine; 1H-imidazole; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol203088g