(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

Base Information

Chemical Name:(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn
CAS No.:1358918-41-8
Molecular Formula:C₃₇H₅₂O₃Si₂
Molecular Weight:600.989
Hs Code.:

Synonyms:(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

Suppliers and Price of (5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

Chemical Property:

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Technology Process of (5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

There total 8 articles about (5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1358918-34-9
(5S)-8-benzyloxy-1-(tert-butyldiphenylsilyloxy)oct-2-yn-5-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1358918-41-8
(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol203088g

Reference yield:

: C₁₂H₁₆O₄S

: 1358918-41-8
(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile / 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; n-butyllithium; ruthenium(III) chloride trihydrate; In tetrahydrofuran; hexanes; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol203088g

Reference yield:

: 1358918-33-8
C₁₂H₁₆O₅S

: 1358918-41-8
(5S)-8-benzyloxy-5-t-butyldimethylsilyloxy-1-(t-butyldiphenylsilyloxy)oct-2-yn

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexanes; N,N-dimethyl-formamide;
DOI:10.1021/ol203088g