(4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Base Information

Chemical Name:(4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone
CAS No.:1396778-62-3
Molecular Formula:C₂₁H₂₄FN₃O
Molecular Weight:353.439
Hs Code.:

Synonyms:(4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Suppliers and Price of (4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

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Technology Process of (4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

There total 2 articles about (4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1280786-82-4
1-bromo-4-fluoro-5-(pyrrolidin-N-yl)benzene

: 56227-55-5,79332-89-1
N-benzoylpiperazine hydrochloride

: 1396778-62-3
(4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: With sodium t-butanolate; tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 80 ℃; Inert atmosphere; Sealed vessel;

Reference yield:

: 2924-09-6
5-bromo-2-fluoroaniline

: 1396778-62-3
(4-(4-fluoro-3-(pyrrolidin-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C / Sealed vessel

2: sodium t-butanolate / tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 80 °C / Inert atmosphere; Sealed vessel

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one;