Technology Process of methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate
There total 6 articles about methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 22.0 g / sodium methanolate / methanol / 2.25 h / 0 °C
2: 7.3 g / methanol / 1.) 40 deg C, 2 h, 2.) 50 deg C, 5 h
3: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h
4: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature
7: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h
With
manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; sodium methylate; triethylamine;
In
methanol; diethyl ether;
DOI:10.1021/jm00163a011
- Guidance literature:
-
Multi-step reaction with 4 steps
1: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature
4: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h
With
manganese(IV) oxide; sodium tetrahydroborate; triethyl borane; triethylamine;
In
diethyl ether;
DOI:10.1021/jm00163a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h
2: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature
5: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h
With
manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; triethylamine;
In
diethyl ether;
DOI:10.1021/jm00163a011
