N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

Base Information

Chemical Name:N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
CAS No.:1426551-45-2
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

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Chemical Property of N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

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Technology Process of N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

There total 13 articles about N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1609626-96-1
C₂₈H₄₁NO₄Si

: 1426551-45-2
N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ja5030707

Reference yield:

: 700-13-0
Trimethylhydroquinone

: 1426551-45-2
N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 3 h / 85 °C / Inert atmosphere

2: N-Bromosuccinimide / acetonitrile; water / 1 h / 20 °C

3: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 5 h / -55 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 4-methyl-morpholine; N-Bromosuccinimide; methanesulfonic acid; tetrabutyl ammonium fluoride; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.orglett.8b01409

Reference yield:

: 40662-29-1
3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid

: 1426551-45-2
N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / dichloromethane / 0.17 h / -55 °C

2: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 5 h

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 4-methyl-morpholine; tetrabutyl ammonium fluoride; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja5030707