Technology Process of (3S,12S)-1-Benzyloxy-12-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-hexadecan-3-ol
There total 6 articles about (3S,12S)-1-Benzyloxy-12-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-hexadecan-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 1,2-dibromoethane, Mg / 2.) 1,5-cyclooctadienecopper(I) chloride / 1.) THF, reflux, 2.) r.t.
2: 93 percent / imidazole / dimethylformamide / 16 h / Ambient temperature
3: 97 percent / H2 / 5percent Pd/BaSO4 / methanol; ethyl acetate; acetic acid / 2 h / 750.06 Torr
4: 90 percent / CBr4, Ph3P / CH2Cl2 / 4 h / Ambient temperature
5: 1.) 1,2-dibromoethane, Mg / 2.) 1,5-cyclooctadienecopper(I) chloride / 1.) THF, reflux, reflux, 60 min, 2.) 20 deg C, 90 min
With
1H-imidazole; carbon tetrabromide; hydrogen; magnesium; ethylene dibromide; triphenylphosphine;
Pd-BaSO4;
In
methanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jlac.199619961226
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 1,2-dibromoethane, Mg / 2.) 1,5-cyclooctadienecopper(I) chloride / 1.) THF, reflux, 2.) r.t.
2: 93 percent / imidazole / dimethylformamide / 16 h / Ambient temperature
3: 97 percent / H2 / 5percent Pd/BaSO4 / methanol; ethyl acetate; acetic acid / 2 h / 750.06 Torr
4: 90 percent / CBr4, Ph3P / CH2Cl2 / 4 h / Ambient temperature
5: 1.) 1,2-dibromoethane, Mg / 2.) 1,5-cyclooctadienecopper(I) chloride / 1.) THF, reflux, reflux, 60 min, 2.) 20 deg C, 90 min
With
1H-imidazole; carbon tetrabromide; hydrogen; magnesium; ethylene dibromide; triphenylphosphine;
Pd-BaSO4;
In
methanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jlac.199619961226
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / CBr4, Ph3P / CH2Cl2 / 4 h / Ambient temperature
2: 1.) 1,2-dibromoethane, Mg / 2.) 1,5-cyclooctadienecopper(I) chloride / 1.) THF, reflux, reflux, 60 min, 2.) 20 deg C, 90 min
With
carbon tetrabromide; magnesium; ethylene dibromide; triphenylphosphine;
2.) 1,5-cyclooctadienecopper(I) chloride;
In
dichloromethane;
DOI:10.1002/jlac.199619961226