(S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

Base Information

Chemical Name:(S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate
CAS No.:161288-08-0
Molecular Formula:C₁₃H₁₄F₃NO₄
Molecular Weight:305.254
Hs Code.:

Synonyms:(S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

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Chemical Property of (S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

Chemical Property:

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Technology Process of (S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

There total 4 articles about (S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.3%

: (2S)-methyl 2-benzyloxycarbonylamino-3-<(4-methylphenyl)sulfenyl>-2-trifluoromethyl propionate

: 161288-08-0
(S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

Guidance literature:: With hydrogen; nickel; In ethanol; at 80 ℃; for 6h;
DOI:10.1016/S0957-4166(00)86276-X

Reference yield:

: 128970-26-3
2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester

: 161288-08-0
(S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -60 deg C, 5 min, 2.) THF, -70 deg C, 5 min

2: 97.7 percent / (CF₃CO)2O, NaI / acetone / 0.08 h / -20 °C

3: 25.3 percent / H₂ / Raney Ni / ethanol / 6 h / 80 °C

With hydrogen; trifluoroacetic anhydride; sodium iodide; lithium diisopropyl amide; nickel; In ethanol; acetone;
DOI:10.1016/S0957-4166(00)86276-X

Reference yield:

: 81357-08-6
benzyl (triphenyl-λ⁵-phosphanilidene)carbamate

: 161288-08-0
(S)-methyl 2-benzyloxycarbonylamino-2-methyl-3,3,3-trifluoromethyl propionate

Guidance literature:: Multi-step reaction with 4 steps

1: benzene

2: 1.) LDA / 1.) THF, -60 deg C, 5 min, 2.) THF, -70 deg C, 5 min

3: 97.7 percent / (CF₃CO)2O, NaI / acetone / 0.08 h / -20 °C

4: 25.3 percent / H₂ / Raney Ni / ethanol / 6 h / 80 °C

With hydrogen; trifluoroacetic anhydride; sodium iodide; lithium diisopropyl amide; nickel; In ethanol; acetone; benzene;
DOI:10.1016/S0957-4166(00)86276-X