C₂₁H₂₆BrFN₄O₃

Base Information

• Chemical Name: C₂₁H₂₆BrFN₄O₃
• CAS No.: 1261117-73-0
• Molecular Formula: C₂₁H₂₆BrFN₄O₃
• Molecular Weight: 481.365
• Mol file: 1261117-73-0.mol

Synonyms:C₂₁H₂₆BrFN₄O₃

Chemical Property of C₂₁H₂₆BrFN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆BrFN₄O₃

There total 5 articles about C₂₁H₂₆BrFN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

tert-butyl 2-(3-bromo-2-(4-fluorophenyl)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethylcarbamate (1261118-06-2) → C21H26BrFN4O3 (1261117-73-0)

Guidance literature:

With bromine; acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm300041e

Reference yield:

C18H16FN3O2 (1261118-48-2) → C21H26BrFN4O3 (1261117-73-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 20 - 40 °C

2: methanesulfonic acid; acetic acid / 12 h / Sealed tube; Heating

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: bromine; acetic acid / dichloromethane / 0.5 h / 20 °C

With methanesulfonic acid; bromine; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300041e

Reference yield:

C22H22FN3O2 (1261118-40-4) → C21H26BrFN4O3 (1261117-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: methanesulfonic acid; acetic acid / 12 h / Sealed tube; Heating

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: bromine; acetic acid / dichloromethane / 0.5 h / 20 °C

With methanesulfonic acid; bromine; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300041e

upstream raw materials:

BOC-glycine

C₁₈H₁₆FN₃O₂

C₂₂H₂₂FN₃O₂

C₁₄H₁₆FN₃

Downstream raw materials:

2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone