Technology Process of benzyl (2S,3R)-2-isopropyl-5-oxopyrrolidin-3-ylcarbamate
There total 9 articles about benzyl (2S,3R)-2-isopropyl-5-oxopyrrolidin-3-ylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
methanol; water;
Inert atmosphere;
DOI:10.1039/c2ob26828k
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydrogencarbonate / water / Inert atmosphere
2.1: triethylamine / Inert atmosphere
3.1: ammonium hydroxide / tetrahydrofuran / Inert atmosphere
4.1: trichlorophosphate; pyridine / Inert atmosphere
5.1: sodium hydride / N,N-dimethyl-formamide / Inert atmosphere
6.1: zinc / tetrahydrofuran / Inert atmosphere
6.2: Inert atmosphere
7.1: sodium cyanoborohydride; hydrogenchloride / dichloromethane; methanol / Inert atmosphere
8.1: hydrogen; palladium(II) hydroxide / methanol
9.1: hydrogenchloride; water / Inert atmosphere; Reflux
10.1: sodium hydrogencarbonate / water; methanol / Inert atmosphere
With
pyridine; hydrogenchloride; ammonium hydroxide; water; hydrogen; palladium(II) hydroxide; sodium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; zinc; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob26828k
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ammonium hydroxide / tetrahydrofuran / Inert atmosphere
2.1: trichlorophosphate; pyridine / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / Inert atmosphere
4.1: zinc / tetrahydrofuran / Inert atmosphere
4.2: Inert atmosphere
5.1: sodium cyanoborohydride; hydrogenchloride / dichloromethane; methanol / Inert atmosphere
6.1: hydrogen; palladium(II) hydroxide / methanol
7.1: hydrogenchloride; water / Inert atmosphere; Reflux
8.1: sodium hydrogencarbonate / water; methanol / Inert atmosphere
With
pyridine; hydrogenchloride; ammonium hydroxide; water; hydrogen; palladium(II) hydroxide; sodium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; zinc; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob26828k
