3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

Base Information

Chemical Name:3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile
CAS No.:163562-09-2
Molecular Formula:C₂₀H₁₈N₂O₂S
Molecular Weight:350.441
Hs Code.:

3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benz<e>indole-8-carbonitrile

Synonyms:3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

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Chemical Property of 3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

Chemical Property:

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Technology Process of 3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

There total 1 articles about 3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2942-58-7
diethyl cyanophosphonate

: 155591-01-8
3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

: 163562-09-2
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

Guidance literature:: With samarium; 1,1-diiodoethane; lithium cyanide; Yield given. Multistep reaction; 1.) THF, 30 min, 2.) THF, t-BuOH, 1 h;
DOI:10.1021/jm00012a022

Reference yield: 82.0%

: 163562-09-2
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

: 163562-10-5
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm00012a022

Reference yield:

: 163562-09-2
3-N-(tolylsulfonyl)-6,7,8,9-tetrahydro-3H-benzindole-8-carbonitrile

: 1028260-83-4
Dipropyl-[3-(toluene-4-sulfonyl)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-ylmethyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / diisobutylaluminum hydride / CH₂Cl₂ / 2 h / 0 °C

2: 1.) acetic acid, 2.) NaCNBH₃ / 1.) MeOH, THF, 30 min, 2.) MeOH, THF, RT, 2 h

With diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; In dichloromethane;
DOI:10.1021/jm00012a022