8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

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Chemical Name:8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate
CAS No.:135246-03-6
Molecular Formula:C₂₉H₃₂N₂O₇
Molecular Weight:520.582
Hs Code.:
Mol file:135246-03-6.mol

8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

Synonyms:8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

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Chemical Property of 8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate Edit

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Technology Process of 8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

There total 2 articles about 8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 135246-02-5
8-benzyl-5-methyl (+)-(4aS,5R,7aR,9R,10aS)-2-benzyl-9-<(tert-butyldiphenylsilyl)oxymethyl>-1,7-dioxo-2,3,4,4a,5,6,7a,9,10-nonahydro-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

: 135246-03-6
8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1.5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96112-5

Reference yield:

: 128572-26-9
8-benzyl-5-methyl (-)-(4aS,5R,9R,10aS)-2-benzyl-9-<(tert-butyldiphenylsilyl)oxymethyl>-1-oxo-2,3,4,4a,5,6,9,10-octahydro-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

: 135246-03-6
8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) OsO₄, pyridine, 2) p-toluenesulfonic acid monohydrate / 1) r.t., 16 h, 2) benzene, reflux, 30 min

2: 90 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature

With pyridine; osmium(VIII) oxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)96112-5