LFM-A13

Base Information

Chemical Name:LFM-A13
CAS No.:244240-24-2
Molecular Formula:C11H8 Br2 N2 O2
Molecular Weight:360.005
Hs Code.:
Mol file:244240-24-2.mol

Synonyms:LFM-A 13

Suppliers and Price of LFM-A13

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LFM-A13
200mg
$ 985.00

TRC
LFM-A13
50mg
$ 380.00

Sigma-Aldrich
LFM-A13 ≥98% (HPLC), powder
5mg
$ 107.00

Sigma-Aldrich
LFM-A13 ≥98% (HPLC), powder
25mg
$ 417.00

DC Chemicals
LFM-A13 >98%
1 g
$ 1300.00

DC Chemicals
LFM-A13 >98%
100 mg
$ 400.00

Crysdot
LFM-A13 98+%
50mg
$ 223.00

Crysdot
LFM-A13 98+%
10mg
$ 56.00

ChemScene
LFM-A13 99.97%
10mg
$ 96.00

ChemScene
LFM-A13 99.97%
5mg
$ 60.00

Total 12 raw suppliers

Chemical Property of LFM-A13

Chemical Property:

PSA：73.12000
LogP:3.57868
Storage Temp.:−20°C
Solubility.:DMSO: 15 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

LFM-A13 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Description LFM-A13 (244240-24-2) is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC50‘s = 2.5 μM (recombinant BTK) and 17.2 μM (human BTK).1,2 It has also been shown to inhibit Polo-like kinase (PLK) – IC50 = 61 μM for human PLK3.3 LFM-A13 displayed no activity (concentrations up to 278 μM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten other tyrosine kinases.3
Uses LFM-A13 is a potent inhibitor of Polo-like kinase (PLK), used for anti-breast cancer activity. Also a specific Bruton’s tyrosine kinase inhibitor.

Technology Process of LFM-A13

There total 3 articles about LFM-A13 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 63034-99-1
N-(2,5-dibromophenyl)-2-cyanoacetamide

: 108-24-7
acetic anhydride

: 244240-24-2,62004-35-7
(2Z)-N-(2,5-dibromophenyl)-2-cyano-3-hydroxybut-2-enamide

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 20 ℃;

Reference yield: 78.0%

: 63034-99-1
N-(2,5-dibromophenyl)-2-cyanoacetamide

: 75-36-5
acetyl chloride

: 244240-24-2,62004-35-7
(2Z)-N-(2,5-dibromophenyl)-2-cyano-3-hydroxybut-2-enamide

Guidance literature:: N-(2,5-dibromophenyl)-2-cyanoacetamide; With sodium hydride; In tetrahydrofuran; at -0.15 ℃; for 1h;

acetyl chloride; In tetrahydrofuran; for 1h; room t.;
DOI:10.1107/S0108270199005727

Reference yield:

: 3638-73-1
2,5-dibromoaniline

: 244240-24-2,62004-35-7
(2Z)-N-(2,5-dibromophenyl)-2-cyano-3-hydroxybut-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 1,3-diisopropylcarbodiimide / ethyl acetate / 24 h / 20 °C

2: 79 percent / sodium tert-butoxide / tetrahydrofuran / 20 °C

With sodium t-butanolate; diisopropyl-carbodiimide; In tetrahydrofuran; ethyl acetate;