2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Base Information

Chemical Name:2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide
CAS No.:1613639-03-4
Molecular Formula:C₂₁H₁₈N₄O₂
Molecular Weight:358.4
Hs Code.:

Synonyms:2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

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Chemical Property of 2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

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Technology Process of 2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

There total 5 articles about 2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 376584-62-2
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one

: 1569320-04-2
2-(5-bromopyridin-3-ylamino)-2-phenylacetamide

: 1613639-03-4
2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: With potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613639-03-4
2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 90 °C / Inert atmosphere

2.1: ammonia; triethylamine / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 90 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; ammonia; potassium carbonate; triethylamine; L-proline; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 552330-86-6
5-bromoisoindolin-1-one

: 1613639-03-4
2-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridin-3-ylamino]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; catacxium A / Isopropyl acetate / 1 h / 83 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 90 °C / Inert atmosphere; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; potassium carbonate; catacxium A; In 1,2-dimethoxyethane; Isopropyl acetate; water;