2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Base Information

Chemical Name:2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide
CAS No.:1360114-04-0
Molecular Formula:C₂₃H₁₉Cl₂N₃O₄
Molecular Weight:472.328
Hs Code.:

Synonyms:2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Suppliers and Price of 2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

There total 3 articles about 2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 337358-76-6
3-(3-chloro-benzoyl)-2,6-dichloropyridine

: 21855-72-1
N-[benzyloxycarbonyl]-N'-methyl-glycinamide

: 1360114-04-0
2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.12.045

Reference yield:

: 2402-78-0
2,6-dichloropyridine

: 1360114-04-0
2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diethylamine / tetrahydrofuran; hexane / 1.5 h / -80 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: chromium(VI) oxide / acetone / 0.5 h / 0 - 20 °C

3.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With chromium(VI) oxide; n-butyllithium; palladium diacetate; caesium carbonate; diethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; acetone; 3.1: Buchwald reaction;
DOI:10.1016/j.tetlet.2011.12.045

Reference yield:

: 587-04-2
m-Chlorobenzaldehyde

: 1360114-04-0
2-(benzyloxycarbamoyl)-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diethylamine / tetrahydrofuran; hexane / 1.5 h / -80 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: chromium(VI) oxide / acetone / 0.5 h / 0 - 20 °C

3.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With chromium(VI) oxide; n-butyllithium; palladium diacetate; caesium carbonate; diethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; acetone; 3.1: Buchwald reaction;
DOI:10.1016/j.tetlet.2011.12.045