Technology Process of oxazol-2-yl(5-phenoxyindan-2-yl)methanol
There total 8 articles about oxazol-2-yl(5-phenoxyindan-2-yl)methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
oxazol;
With
borane-THF;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.666667h;
5-phenoxyindane-2-carboxaldehyde;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
2.1: palladium 10% on activated carbon; perchloric acid; hydrogen; acetic acid / 16 h
3.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux
4.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
5.1: copper diacetate / dichloromethane / 0.25 h / 20 °C / Molecular sieve
5.2: 17 h / 20 °C / Inert atmosphere
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
7.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
8.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
8.2: 0.67 h / -78 °C
8.3: 2 h / -78 °C
With
lithium aluminium tetrahydride; perchloric acid; borane-THF; sulfuric acid; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; copper diacetate; sodium hydride; Dess-Martin periodane; acetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
2.1: copper diacetate / dichloromethane / 0.25 h / 20 °C / Molecular sieve
2.2: 17 h / 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
5.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
5.2: 0.67 h / -78 °C
5.3: 2 h / -78 °C
With
lithium aluminium tetrahydride; borane-THF; sulfuric acid; copper diacetate; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101597x
