tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate
CAS No.:1610697-87-4
Molecular Formula:C₂₃H₁₉Cl₂N₅O₄
Molecular Weight:500.341
Hs Code.:

Synonyms:tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

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Chemical Property of tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

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Technology Process of tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

There total 6 articles about tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1610697-86-3
6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 1610697-87-4
tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

Reference yield:

: 123148-78-7
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

: 1610697-87-4
tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: copper diacetate; pyridine / dichloromethane / 120 h / 20 °C / Molecular sieve

2: ammonium hydroxide / 1,4-dioxane / 1 h / 120 °C / Sealed tube

3: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

5: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

With pyridine; ammonium hydroxide; N-chloro-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper diacetate; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1422828-21-4
4-chloro-5-iodo-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1610697-87-4
tert-butyl 6-chloro-5-(4-chlorophenyl)-7-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / 1,4-dioxane / 1 h / 120 °C / Sealed tube

2: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

4: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

With ammonium hydroxide; N-chloro-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;