4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: 4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide
• CAS No.: 1601477-00-2
• Molecular Formula: C₁₀H₁₁F₃N₂O₂S
• Molecular Weight: 280.271
• Mol file: 1601477-00-2.mol

Synonyms:4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide

Chemical Property of 4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide

There total 1 articles about 4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,1,1-trifluoro-2-propanone (421-50-1) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide (1601477-00-2)

Guidance literature:

In diethyl ether; at 45 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.201304143

Reference yield: 99.0%

4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide (1601477-00-2) + C10H9BrO → (E)-3-[4-methyl-2-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]acrylaldehyde

Guidance literature:

With sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; at 100 ℃; for 2h; Microwave irradiation;

DOI:10.1002/adsc.201700975

Reference yield: 94.0%

3-bromo-2-thiophenecarboxaldehyde (930-96-1) + 4-methyl-N'-(1,1,1-trifluoropropan-2-ylidene)benzenesulfonohydrazide (1601477-00-2) → 3-(3,3,3-trifluoro-1-propen-2-yl)thiophene-2-carbaldehyde

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; XPhos; In tetrahydrofuran; at 100 ℃; for 1.5h; Microwave irradiation; Sealed tube;

DOI:10.1021/acs.joc.6b01590

upstream raw materials:

1,1,1-trifluoro-2-propanone

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

1-(benzyloxy)-3-(3,3,3-trifluoroprop-1-en-2-yl)benzene

N-(4-(3,3,3-trifluoroprop-1-en-2-yl)phenyl)acetamide

phenyl(2-(3,3,3-trifluoroprop-1-en-2-yl)phenyl)methanone

2-(3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl)-1,3-dioxolane