2,4-Bis-trifluoromethyl-phenol

Base Information

• Chemical Name: 2,4-Bis-trifluoromethyl-phenol
• CAS No.: 908848-70-4
• Molecular Formula: C₈H₄F₆O
• Molecular Weight: 230.11
• Mol file: 908848-70-4.mol

Synonyms:2,4-bis(trifluoromethyl)phenol

Chemical Property of 2,4-Bis-trifluoromethyl-phenol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

2,4-bis(Trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Bis-trifluoromethyl-phenol

There total 3 articles about 2,4-Bis-trifluoromethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2,4-bis(trifluoromethyl)aniline (367-71-5) → 2,4-bis(trifluoromethyl)phenol (908848-70-4)

Guidance literature:

2,4-bis(trifluoromethyl)aniline; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 3h;

With urea; In water; at 0 ℃; for 0.166667h;

With sulfuric acid; water; for 1h; Heating / reflux;

Reference yield:

C13H6F6O2S → 2,4-bis(trifluoromethyl)phenol (908848-70-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 40 ℃;

DOI:10.1002/anie.202108971

Reference yield:

2,4-bis(trifluoromethyl)benzoic acid (32890-87-2) → 2,4-bis(trifluoromethyl)phenol (908848-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / acetonitrile; water / 1 h / 25 °C

1.2: 15 h / 35 °C / Irradiation; Inert atmosphere; Glovebox

2.1: lithium hydroxide / tetrahydrofuran; methanol / 40 °C

With lithium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;

DOI:10.1002/anie.202108971

upstream raw materials:

2,4-bis(trifluoromethyl)aniline

2,4-bis(trifluoromethyl)benzoic acid

Downstream raw materials:

2-(2,4-bis-trifluoromethyl-phenoxy)-ethylamine

(4-{4-[2-(2,4-bis-trifluoromethyl-phenoxy)-ethylcarbamoyl]-5-methyl-isoxazol-3-yl}-3-chloro-phenyl)-acetic acid methyl ester

[2-(2,4-bis-trifluoromethyl-phenoxy)-ethyl]-carbamic acid tert-butyl ester

dimethyl-thiocarbamic acid O-(2,4-bis-trifluoromethyl-phenyl) ester

Refernces

• 1、 -. "NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF". Page/Page column 15. . Retrieved 2008/12/08.