N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

Base Information

Chemical Name:N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide
CAS No.:1352440-56-2
Molecular Formula:C₂₁H₂₁ClF₃N₃O₅
Molecular Weight:487.863
Hs Code.:

Synonyms:N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

Chemical Property:

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Technology Process of N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

There total 4 articles about N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1352440-77-7
ethyl 7-[4-hydroxy-3-(N-4-chloro-3-trifluoromethylphenylcarbamoyl)phenylamino]-7-oxoheptanoate

: 1352440-56-2
N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; Cooling with ice;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 33018-91-6
7-ethoxy-7-oxoheptanoic acid

: 1352440-56-2
N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

3: hydroxylamine hydrochloride; potassium hydroxide / methanol / Cooling with ice

With thionyl chloride; hydroxylamine hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 1352440-75-5
N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-nitrobenzamide

: 1352440-56-2
N-(4-chloro-3-trifluoromethylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

1.2: pH 10 / Saturated solution

2.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / Cooling with ice

With hydroxylamine hydrochloride; iron; acetic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmc.2012.05.034