(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

Base Information

Chemical Name:(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol
CAS No.:863403-18-3
Molecular Formula:C₂₉H₃₃NO₅S
Molecular Weight:507.651
Hs Code.:

Synonyms:(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

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Technology Process of (+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

There total 9 articles about (+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 863403-10-5
(R)-(E)-5-(4-methoxyphenyl)-4-(4-methylbenzylamino)pent-2-en-1-ol

: 3937-96-0
tosylacetic acid

: 863403-18-3
(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1039/b504731e

Reference yield:

: 863403-38-7
(R)-(E)-4-amino-5-(4-methoxyphenyl)pent-2-en-1-ol

: 863403-18-3
(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.00 g / 4 Angstroem molecular sieves; AcOH / methanol; tetrahydrofuran / 1 h / 20 °C

2: 1.00 g / NaCNBH₃ / methanol; tetrahydrofuran

3: 91 percent / DCC / CH₂Cl₂ / 15 h / 20 °C

With 4 A molecular sieve; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b504731e

Reference yield:

: N-[1-formyl-2-(4-methoxy-phenyl)-ethyl]-4-methyl-benzenesulfonamide

: 863403-18-3
(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.60 g / CH₂Cl₂ / 12 h / 20 °C

2: 76 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: 1.1 g / Na; NH₃ / 0.5 h / -78 °C

4: 1.00 g / 4 Angstroem molecular sieves; AcOH / methanol; tetrahydrofuran / 1 h / 20 °C

5: 1.00 g / NaCNBH₃ / methanol; tetrahydrofuran

6: 91 percent / DCC / CH₂Cl₂ / 15 h / 20 °C

With 4 A molecular sieve; ammonia; sodium; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; 1: Wittig homologation;
DOI:10.1039/b504731e