(+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

Base Information

Chemical Name:(+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester
CAS No.:863403-08-1
Molecular Formula:C₃₁H₃₅NO₇S
Molecular Weight:565.687
Hs Code.:

Synonyms:(+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

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Chemical Property of (+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

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Technology Process of (+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

There total 10 articles about (+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 863403-18-3
(+)-(R)-(E)-5-(4-methoxyphenyl)-4-{(4-methylbenzyl)[(toluene-4-sulfonyl)acetyl]amino}pent-2-enol

: 79-22-1
methyl chloroformate

: 863403-08-1
(+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1039/b504731e

Reference yield:

: 863403-38-7
(R)-(E)-4-amino-5-(4-methoxyphenyl)pent-2-en-1-ol

: 863403-08-1
(+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.00 g / 4 Angstroem molecular sieves; AcOH / methanol; tetrahydrofuran / 1 h / 20 °C

2: 1.00 g / NaCNBH₃ / methanol; tetrahydrofuran

3: 91 percent / DCC / CH₂Cl₂ / 15 h / 20 °C

4: 96 percent / pyridine; DMAP / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; 4 A molecular sieve; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b504731e

Reference yield:

: N-[1-formyl-2-(4-methoxy-phenyl)-ethyl]-4-methyl-benzenesulfonamide

: 863403-08-1
(+)-(R)-(E)-carbonic acid 5-(4-methoxyphenyl)-4-[(4-methylbenzyl)-2-(toluene-4-sulfonyl)acetylamino]pent-2-enyl ester methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.60 g / CH₂Cl₂ / 12 h / 20 °C

2: 76 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: 1.1 g / Na; NH₃ / 0.5 h / -78 °C

4: 1.00 g / 4 Angstroem molecular sieves; AcOH / methanol; tetrahydrofuran / 1 h / 20 °C

5: 1.00 g / NaCNBH₃ / methanol; tetrahydrofuran

6: 91 percent / DCC / CH₂Cl₂ / 15 h / 20 °C

7: 96 percent / pyridine; DMAP / CH₂Cl₂ / 1 h / 20 °C

With pyridine; dmap; 4 A molecular sieve; ammonia; sodium; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; 1: Wittig homologation;
DOI:10.1039/b504731e