F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

Base Information

• Chemical Name: F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester
• CAS No.: 1369355-91-8
• Molecular Formula: C₁₉H₁₈FNO₄
• Molecular Weight: 343.355

Synonyms:F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

Chemical Property of F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

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Technology Process of F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

There total 4 articles about F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C15H14FNO + oxalic acid diethyl ester (95-92-1) → F.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester (1369355-91-8)

Guidance literature:

With sodium ethanolate; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm401040b

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) → F.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester (1369355-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 90 °C

2: sodium hydroxide / 24 h / 25 °C

3: sodium ethanolate / tetrahydrofuran / 25 °C

With sodium ethanolate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.2174/092986711796504619

Reference yield:

1-(4-fluorobenzyl)-1H-pyrrole-2-carboxaldehyde (883541-16-0) → F.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester (1369355-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 24 h / 25 °C

2: sodium ethanolate / tetrahydrofuran / 25 °C

With sodium ethanolate; sodium hydroxide; In tetrahydrofuran;

DOI:10.2174/092986711796504619

upstream raw materials:

2-pyrrole aldehyde

oxalic acid diethyl ester

1-(4-fluorobenzyl)-1H-pyrrole-2-carboxaldehyde

4-Fluorobenzyl bromide

Downstream raw materials:

6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

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