N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

Base Information

Chemical Name:N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide
CAS No.:1616808-64-0
Molecular Formula:C₁₇H₁₅F₃N₂O₃S
Molecular Weight:384.379
Hs Code.:

Synonyms:N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

Chemical Property:

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Technology Process of N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

There total 7 articles about N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616808-65-1
3-(cyclopropanesulfonamido)-N-(3,4-difluorophenyl)-4-fluorobenzamide

: 74-88-4
methyl iodide

: 1616808-64-0
N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1409792-87-5
3-(cyclopropanesulfonamido)-4-fluorobenzoic acid

: 1616808-64-0
N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 369-26-6
methyl 3-amino-4-fluorobenzoate

: 1616808-64-0
N-(3,4-difluorophenyl)-4-fluoro-3-(N-methylcyclopropanesulfonamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; pyridine / 12 h / 110 °C

2: methanol; lithium hydroxide / 20 °C

3: 2 h / Reflux

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; methanol; dmap; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;