6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one

Base Information

• Chemical Name: 6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one
• CAS No.: 1229443-12-2
• Molecular Formula: C₂₉H₂₄BrNO₃
• Molecular Weight: 514.418

Synonyms:6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one

Chemical Property of 6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

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Technology Process of 6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one

There total 1 articles about 6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one (1229443-11-1) → 6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one (1229443-12-2)

Guidance literature:

With N-Bromosuccinimide; sodium acetate; In N,N-dimethyl-formamide; at 20 ℃; for 5h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja103183r

Reference yield: 63.0%

6-bromo-3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one (1229443-12-2) + methyl iodide (74-88-4) → (3S,4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol (1229443-13-3)

Guidance literature:

With ethanol; silver carbonate; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja103183r

upstream raw materials:

3-((1R,2S)-2,4-dihydroxy-2-(naphthalen-1-yl)-1-phenylbutyl)quinolin-2(1H)-one

Downstream raw materials:

(3S,4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

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