5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

Base Information

Chemical Name:5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride
CAS No.:1258283-55-4
Molecular Formula:C₂₁H₂₅ClN₄O₂S*ClH
Molecular Weight:469.435
Hs Code.:

Synonyms:5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

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Chemical Property of 5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

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Technology Process of 5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

There total 5 articles about 5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1258283-44-1
5-dimethylamino-pentanoic acid (4-amino-phenyl)-amide

: 540-72-7
sodium thiocyanide

: 122-01-0
4-chloro-benzoyl chloride

: 1258283-55-4
5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

Guidance literature:: sodium thiocyanide; 4-chloro-benzoyl chloride; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

5-dimethylamino-pentanoic acid (4-amino-phenyl)-amide; In acetone; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; acetone;
DOI:10.1016/j.bmc.2012.01.001

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 1258283-55-4
5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: dichloromethane; water / 24 h

3.1: palladium 10% on activated carbon; hydrogen / methanol

4.1: acetone / 0.5 h / 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2012.01.001

Reference yield:

: 1258283-45-2
benzyl 4-(5-bromopentanamido)phenylcarbamate

: 1258283-55-4
5-dimethylamino-pentanoic acid {4-[3-(4-chloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane; water / 24 h

2.1: palladium 10% on activated carbon; hydrogen / methanol

3.1: acetone / 0.5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2012.01.001