(E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

Base Information

Chemical Name:(E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran
CAS No.:1431465-49-4
Molecular Formula:C₂₃H₁₈F₂O₂
Molecular Weight:364.392
Hs Code.:

Synonyms:(E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

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Technology Process of (E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

There total 3 articles about (E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1431465-62-1
2-bromo-4-fluoro-1-(3-(4-methoxyphenyl)prop-2-ynyloxy)benzene

: 139911-27-6
4-fluoro-3-methylphenyl boronic acid

: 1431465-49-4
(E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In 1,4-dioxane; at 100 ℃; for 1h;
DOI:10.1021/jo400503f

Reference yield:

: 457628-49-8
2-bromo-4-fluoro-1-(prop-2-yn-1-yloxy)benzene

: 1431465-49-4
(E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / 1,4-dioxane / 1 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo400503f

Reference yield:

: 696-62-8
para-iodoanisole

: 1431465-49-4
(E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / 1,4-dioxane / 1 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo400503f