457628-49-8

Upstream product

• 672946-37-1 2,4-difluoro-1-(prop-2-yn-1-yloxy)benzene 
• 496-69-5 2-bromo-4-fluoro-phenol 
• 106-96-7 propargyl bromide 
• 6921-27-3 dipropargyl ether 

Downstream Products

• 1527494-39-8 2-bromo-4-fluoro-1-((3-(2-phenoxyphenyl)prop-2-yn-1-yl)oxy)benzene 
• 1275380-84-1 2-bromo-4-fluoro-1-(3-phenylprop-2-ynyloxy)benzene 
• 1431465-63-2 1-(4-(3-(2-bromo-4-fluorophenoxy)prop-1-ynyl)phenyl)ethanone 
• 1431465-62-1 2-bromo-4-fluoro-1-(3-(4-methoxyphenyl)prop-2-ynyloxy)benzene 
• 1431465-56-3 5-fluoro-3-((4-methoxyphenyl)(phenyl)methyl)benzofuran 
• 1431465-50-7 (E)-1-(4-((4-fluoro-3-methylphenyl)(5-fluorobenzofuran3(3H)-ylidene)methyl)phenyl)ethanone 
• 1431465-49-4 (E)-5-fluoro-3-((4-fluoro-3-methylphenyl)(4-mthoxyphenyl)methylene)-2,3-dihydrobenzofuran 
• 1431465-38-1 (Z)-5-fluoro-3-((4-methoxyphenyl)(phenyl)methylene)-2,3-dihydrobenzofuran 
• 1431465-37-0 (Z)-methyl 4-((5-fluorobenzofuran-3(2H)-ylidene)(4-methoxyphenyl)methyl)benzoate 
• 1431465-36-9 (Z)-1-(4-((5-fluorobenzofuran-3(2H)-ylidene)(phenyl)methyl)phenyl)ethanone 
• 1431465-35-8 (E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate 
• 1431465-33-6 (E)-methyl 3-((5-fluorobenzofuran-3(2H)-ylidene)(phenyl)methyl)benzoate 
• 1431465-32-5 (E)-methyl 4-((5-fluorobenzofuran-3(2H)-ylidene)(phenyl)methyl)benzoate 

Relevant academic research and scientific papers

Iron-Mediated Cyclization of 1,3-Diynyl Propargyl Aryl Ethers with Dibutyl Diselenide: Synthesis of Selenophene-Fused Chromenes

The synthesis of selenophene-fused chromene derivatives starting from 1,3-diynyl propargyl aryl ethers is reported herein. The method is based on carbon-carbon, carbon-selenium, selenium-carbon and carbon-selenium bonds formation in a one-pot protocol, using iron(III) chloride and dibutyl diselenide as promoters. The same reaction conditions were applied to propargyl anilines leading to the formation of 1-(butylselanyl)-selenophene quinolines. The results showed that the dilution and temperature of substrate addition had a crucial influence in the products obtained. When the substrates were added at room temperature, in the absence of a solvent, a mixture of products was obtained, whereas the slowly addition (15 min) of starting materials, as a dichloromethane solution, at 0 °C led to the product formation in good yields. The mechanistic study indicates that the cooperative action between iron(III) chloride and dibutyl diselenide was essential to promote the cyclization, whereas separately none of them was effective in promoting the cyclization. We proved the synthetic utility of heterocycles obtained in the Suzuki cross coupling reaction, giving the corresponding cross-coupled products in good yields. In addition, the organoselenium moiety was removed from the structures of products by using n-butyllithium. (Figure presented.).

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.

Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities

Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme essential to pyrimidine de novo biosynthesis, which serves as an attractive therapeutic target for the treatment of autoimmune disorders. A novel series of hDHODH inhibitors was deve

Gold(I)-Catalyzed Dearomative [2+2]-Cycloaddition of Indoles with Activated Allenes: A Combined Experimental-Computational Study

The gold-catalyzed synthesis of methylidene 2,3-cyclobutane-indoles is documented through a combined experimental/computational investigation. Besides optimizing the racemic synthesis of the tricyclic indole compounds, the enantioselective variant is pres

A convenient method for the synthesis of (prop-2-ynyloxy)benzene derivatives via reaction with propargyl bromide, their optimization, scope and biological evaluation

A highly convenient method has been developed for the synthesis of (prop-2-ynyloxy) benzene and its derivatives. Differently substituted phenol and aniline derivatives were allowed to react with propargyl bromide in the presence of K2CO3/

A facile synthesis of 3-substituted benzofurans and indoles through a palladium-catalyzed domino carbopalladation/CH-activation/isomerization process

Novel benzofurans 7 and indoles 8 have been prepared from 3 and 4 by a Pd-catalyzed mono-component three-fold domino carbopalladation/CH-activation/ isomerization process and from 12 and 5 to give 8 by a two-component fourfold domino Sonogashira/carbopall

NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from -S(=O)pRa, where Ra is -C1-C4 alkyl, -ORx, -NRxRx, -NHNRxRx, - NHNHC(=O)ORx, -NRxOH; -C(=O)-Rb, where Rb is -CT-C4-alkyl, ORx, -NRxRx, -NHNRxRx, -NHC1-C3-alkyl-C(=O)Orx -NRxRc, where Rc is H, C1-C4 alkyl, -NRxRx; -C(=0)Rd, -CN, S(=O)pRx where Rd is Rd is C1-C4-alkyl, -ORx, -NRxRx C1-C3-alkyl-O-Cl-C3alkylC(=O)ORx, -C1-C3-alkyl-COORx; -C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O-Cl-C3alkyl)q-O-Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, -S(=O),- or -CH2-, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is -(CR8R8')n-D-(CR8R8')m-; D is a bond, -NR9-, -0-, -S-, -S(=0)- or -S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.

Non-nucleoside reverse transcriptase inhibitors

Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is H, C1-C3 alkyl, R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto; X is —(CHR8)n-—D—(CHR8)m—; D is —NR9—, —O—, —S—, —S(═O)— or —S(═O)2—; R8 is independently H, C1-C3 alkyl, halo substitutedC1-C3alkyl; R9 is H, C1-C3 alkyl; n and m are independently 0, 1 or 2; and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particularly drug escape mutants.