diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Base Information

Chemical Name:diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate
CAS No.:459167-87-4
Molecular Formula:C₂₈H₃₂O₅S₂
Molecular Weight:512.691
Hs Code.:

Synonyms:diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Suppliers and Price of diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

There total 5 articles about diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4551-15-9
phenylthiotrimethylsilane

: 208401-64-3
diethyl 2-(3,3-dimethyloxypropyl)-2-(6-oxocyclohex-1-enyl)malonate

: 459167-87-4
diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 - 20 ℃;
DOI:10.1039/b202752f

Reference yield:

: 57346-40-4
diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate

: 459167-87-4
diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / TMSOTf / 0.33 h / 0 °C

2.1: 75 percent / Dabco / toluene / 1.5 h / Heating

3.1: NaH / dimethylformamide / 1 h / 0 °C

3.2: 68 percent / Bu₄NI / dimethylformamide / 21 h / 60 °C

4.1: 98 percent / TMSOTf / CH₂Cl₂ / -78 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; trimethylsilyl trifluoromethanesulfonate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b202752f

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 459167-87-4
diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / LDA / tetrahydrofuran / 0.75 h / -78 °C

2.1: 80 percent / TMSOTf / 0.33 h / 0 °C

3.1: 75 percent / Dabco / toluene / 1.5 h / Heating

4.1: NaH / dimethylformamide / 1 h / 0 °C

4.2: 68 percent / Bu₄NI / dimethylformamide / 21 h / 60 °C

5.1: 98 percent / TMSOTf / CH₂Cl₂ / -78 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; trimethylsilyl trifluoromethanesulfonate; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b202752f