2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

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Chemical Name:2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate
CAS No.:1186390-31-7
Molecular Formula:C₃₂H₃₂FN₈O₆P
Molecular Weight:674.628
Hs Code.:

Synonyms:2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

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Chemical Property of 2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

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Technology Process of 2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

There total 7 articles about 2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1186390-09-9
N-(3-fluorophenyl)-2-(3-(7-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)quinazolin-4-ylamino)-1H-pyrazol-5-yl)acetamide

: 1186390-31-7
2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

Guidance literature:: N-(3-fluorophenyl)-2-(3-(7-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)quinazolin-4-ylamino)-1H-pyrazol-5-yl)acetamide; With 1H-tetrazole; dmap; di-tert-butyl N,N-diethylphosphoramidite; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With tert.-butylhydroperoxide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With hydrogenchloride; sodium disulfite;

Reference yield:

: 174891-10-2
(5-amino-2H-pyrazol-3-yl)acetic acid

: 1186390-31-7
2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 2.5 h / 100 - 102 °C

2.1: 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere

4.1: 1H-tetrazole; dmap; di-tert-butyl N,N-diethylphosphoramidite / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.2: 0 - 20 °C

With 1H-tetrazole; dmap; 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; di-tert-butyl N,N-diethylphosphoramidite; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 573675-55-5
7-bromo-4-chloro-quinazoline

: 1186390-31-7
2-(4-(4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoyl)piperazin-1-yl)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 2.5 h / 100 - 102 °C

2.1: 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere

4.1: 1H-tetrazole; dmap; di-tert-butyl N,N-diethylphosphoramidite / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.2: 0 - 20 °C

With 1H-tetrazole; dmap; 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; di-tert-butyl N,N-diethylphosphoramidite; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;