(E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone

Base Information

• Chemical Name: (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone
• CAS No.: 405506-54-9
• Molecular Formula: C₁₄H₁₅ClO₂S
• Molecular Weight: 282.791
• Mol file: 405506-54-9.mol

Synonyms:(E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone

Chemical Property of (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone

There total 5 articles about (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfonyl)ethanol → (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone (405506-54-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)00983-8

Reference yield: 90.0%

chloromethyl phenyl sulfoxide (7205-94-9) + 1-cyclohexenoyl chloride (36278-22-5) → (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone (405506-54-9)

Guidance literature:

chloromethyl phenyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h;

1-cyclohexenoyl chloride; In tetrahydrofuran; at -100 ℃;

DOI:10.1016/S0040-4020(01)00983-8

Reference yield:

cyclohexene-1-carboxylic acid (636-82-8) → (E)-2-chloro-1-(1-cyclohexenyl)-2-(phenylsulfinyl)ethanone (405506-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SOCl₂

2.1: LDA / tetrahydrofuran / 0.17 h / -78 °C

2.2: 90 percent / tetrahydrofuran / -100 °C

With thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)00983-8

upstream raw materials:

chloromethyl phenyl sulfoxide

1-cyclohexenoyl chloride

1-cyclohexene-1-carboxaldehyde

cyclohexene-1-carboxylic acid

Downstream raw materials:

1-cyclohexenylacetic acid