8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Chemical Name:8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one
CAS No.:1401993-20-1
Molecular Formula:C₃₀H₃₄F₃N₃O₄
Molecular Weight:557.613
Hs Code.:

Synonyms:8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Chemical Property of 8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Technology Process of 8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

There total 6 articles about 8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1401995-18-3
(2-methoxy-2-phenylethyl) methanesulfonate

: 3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one, dihydrochloride salt

: 1401993-20-1
8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Microwave irradiation;

Reference yield:

: 2979-22-8
2-methoxy-2-phenylethanol

: 1401993-20-1
8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C / Microwave irradiation

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 617-52-7
Dimethyl itakonate

: 1401993-20-1
8-(2-methoxy-2-phenylethyl)-3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / tetrahydrofuran / 9 h / 0 - 20 °C

1.2: pH ~ 2

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h

2.2: 16 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C / Microwave irradiation

With hydrogenchloride; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;