(E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Base Information

• Chemical Name: (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester
• CAS No.: 33262-65-6
• Molecular Formula: C₁₄H₁₆N₂O₅
• Molecular Weight: 292.291

Synonyms:(E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Chemical Property of (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

There total 6 articles about (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluamidoxime (19227-13-5) + dimethyl acetylenedicarboxylate (762-42-5) → (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester (33262-65-6)

Guidance literature:

In chloroform; at 60 ℃;

DOI:10.1016/j.bmc.2018.02.017

Reference yield:

para-methylbenzonitrile (104-85-8) → (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester (33262-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH / methanol / 60 °C

2: CHCl₃ / 1 h / 60 °C

With hydroxylamine; In methanol; chloroform;

DOI:10.1021/jm070027u

Reference yield:

(Z)-N'-hydroxy-4-methylbenzimidamide (19227-13-5) + dimethyl acetylenedicarboxylate (762-42-5) → (E)-2-[(4-Methyl-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester (33262-65-6)

Guidance literature:

In chloroform; at 60 ℃; for 1h;

DOI:10.1021/jm070027u

upstream raw materials:

p-toluamidoxime

dimethyl acetylenedicarboxylate

para-methylbenzonitrile

(Z)-N'-hydroxy-4-methylbenzimidamide

Downstream raw materials:

methyl 5,6-dihydroxy-2-(4-methylphenyl)pyrimidine-4-carboxylate

methyl 5,6-bis(benzoyloxy)-2-[4-(bromomethyl)phenyl]pyrimidine-4-carboxylate

methyl 5,6-bis(benzoyloxy)-2-(4-methylphenyl)pyrimidine-4-carboxylate

5-benzoyloxy-2-(4-dimethylaminomethyl-phenyl)-6-hydroxy-pyrimidine-4-carboxylic acid methyl ester

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