(+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

Base Information

Chemical Name:(+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam
CAS No.:934831-76-2
Molecular Formula:C₃₃H₄₃NO₄SSi
Molecular Weight:577.86
Hs Code.:

Synonyms:(+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

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Chemical Property of (+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

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Technology Process of (+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

There total 4 articles about (+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 934831-74-0
(+)-(2S)-N-[(1R,2S)-1-hydroxy-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

: 58479-61-1
tert-butylchlorodiphenylsilane

: 934831-76-2
(+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2006.12.018

Reference yield:

: 934831-73-9
(+)-(2S)-N-[(2S,3R)-2-(ethenyl)-3-(hydroxy)-6-heptenoyl]bornane-10,2-sultam

: 934831-76-2
(+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

2: 87 percent / imidazole; DMAP / CH₂Cl₂ / 20 °C

With 1H-imidazole; dmap; Grubbs catalyst first generation; In dichloromethane;
DOI:10.1016/j.tetasy.2006.12.018

Reference yield:

: 2100-17-6
4-pentenal

: 934831-76-2
(+)-(2S)-N-[(1R,2S)-1-(((tert-butyldiphenyl)silyl)oxy)-3-cyclohexene-2-carbonyl]bornane-10,2-sultam

Guidance literature:: Multi-step reaction with 3 steps

1.1: triflic acid; triethylborane; ethyldiisopropylamine / CH₂Cl₂ / cooling

1.2: 87 percent / CH₂Cl₂ / cooling

2.1: 88 percent / Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

3.1: 87 percent / imidazole; DMAP / CH₂Cl₂ / 20 °C

With 1H-imidazole; dmap; triethyl borane; trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In dichloromethane;
DOI:10.1016/j.tetasy.2006.12.018