3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

Base Information

Chemical Name:3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine
CAS No.:259260-14-5
Molecular Formula:C₂₂H₁₆BrN₃O₂S₂
Molecular Weight:498.424
Hs Code.:

Synonyms:3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

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Chemical Property of 3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

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Technology Process of 3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

There total 4 articles about 3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

NH₄ OAc: NH₄ OAc

: 214831-34-2
4-bromo-2-(2,2-dicyanoethenyl)thiophene

: 214831-33-1
2-(3,4-dimethoxyphenyl)-1-(thiophen-2-yl)ethan-1-one

: 259260-14-5
3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

Guidance literature:: In butan-1-ol;

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 259260-14-5
3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / EDCI; HOBt; Et₃N / CH₂Cl₂ / 72 h / 20 °C

2: 50 percent / tetrahydrofuran / 1.5 h

3: NH₄OAc / butan-1-ol / 24 h / Heating

With ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; butan-1-ol;
DOI:10.1021/jm030327l

Reference yield:

: 155955-78-5
3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide

: 259260-14-5
3-cyano-4-(4-bromothien-2-yl)-5-(3,4-dimethoxyphenyl)-6-(thien-2-yl)-2-pyridineamine

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / tetrahydrofuran / 1.5 h

2: NH₄OAc / butan-1-ol / 24 h / Heating

With ammonium acetate; In tetrahydrofuran; butan-1-ol;
DOI:10.1021/jm030327l